Effect of Guanethidine and Adrenal Demedullation on Hyperglycemic Responses to Diazoxide in Rats.

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Abstract
Summary A single intraperitoneal injection of diazoxide, 200 mg/kg, produced a significant elevation of blood sugar and a significant decrease in liver glycogen 3 hours after administration to normal and to de-medullated rats. Guanethidine, 20 mg/kg subcutaneously, had no appreciable effect on blood sugar or liver glycogen of either group. When given together, diazoxide and guanethi-dine also produced a marked elevation in blood sugar and a significant reduction in hepatic glycogen in normal rats. The hyper-glycemic effect of diazoxide was suppressed in the demedullated rats receiving guanethi-dine, although its depleting effect on hepatic glycogen was not attenuated. Generous supplies of diazoxide were made available through the courtesy of Dr. J. Black, Schering Corp., Bloomfield, N. J. The guanethidine supplies were provided by Dr. William Wagner, Ciba Pharmaceutical Co., Summit, N. J.