Oxidation of Thiocyanate, Another Index of Thyroid Function1

Publisher Website
Google Scholar
Abstract
The oxidation of thiocyanate has been studied both in vivo and in vitro. The accumulation and oxidation of thiocyanate have been measured in normal, hypophysectomized, hypophysectomized TSH [thyrotropin] -treated, normal L-thyroxine-treated, and iodine-deficient rats. By and large, the oxidation of thiocyanate by the thyroid parallels that of iodide except in the thyroxine-treated animal. The inhibitors of thiocyanate oxidation are the same as those for iodide oxidation. Iodide administration to rats inhibits thiocyanate oxidation, whereas iodide restriction greatly stimulates this oxidation. These data suggest that the concentration of available iodide in the thyroid is a major regulator of the oxidation of thiocyanate by thyroid tissue. It seems clear that the oxidation of thiocyanate parallels that of iodide; hence, it should be a useful index of thyroid function and may be helpful in dissecting the initial step in iodination.

This publication has 0 references indexed in Scilit: