A C-Glycosidation Approach to the Central Core of Amphidinol 3: Synthesis of the C39−C52 Fragment
- 1 April 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (9) , 1853-1856
- https://doi.org/10.1021/ol050477l
Abstract
A concise route to an advance precursor (3) of the central core of amphidinol 3, a natural occurring polyketide, has been developed by applying a reductive lithiation as key step. The origin of the diastereoselectivity of this reaction was comprehensively studied for nucleophilic C-glycoside donor 5 and differently protected analogues.Keywords
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