Die Eignung von 4.5-Dichlor-pyridazonen-(6) zur selektiven Umsetzung von Mercaptogruppen
- 1 January 1967
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 348 (Jahresband) , 371-377
- https://doi.org/10.1515/bchm2.1967.348.1.371
Abstract
The reaction of 4,5-dichlor-l-(2-carboxyethyl)-pyridazone-(6) with mercaptans was studied by kinetic measurements and by isolation of the reaction products: it is an SN2-reaction with RSo as the nucleophilic agent. The ratio of the rate of reaction with the SH-group of cysteine and the rate of reaction with amino or imidazole groups is about 50 times greater for the above compound than for iodoacetamide and iodoacetate.This publication has 8 references indexed in Scilit:
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