4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1410-1411
- https://doi.org/10.1039/c39930001410
Abstract
Certain members of a series of 4-(sulfonylamino)phenyl α-D-glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 µmol dm–3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 µmol dm–3) against this enzyme.Keywords
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