APOE Genotype Effects on Alzheimer's Disease Onset and Epidemiology
- 1 January 2004
- journal article
- review article
- Published by Springer Nature in Journal of Molecular Neuroscience
- Vol. 23 (3) , 157-166
- https://doi.org/10.1385/jmn:23:3:157
Abstract
The risk of developing Alzheimer’s disease (AD) is tied most closely to age and appears to follow Gompertzian kinetics. However, specific genetic factors are also linked closely to AD, and the apolipoprotein E (APOE) genotype accounts for as much of 50% of the attributable risk for AD in many populations. This paper reviews the onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE genotype and the interaction of the genotype with age.Keywords
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