Renal Metabolism of Rabbit Serum Interferon

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Abstract
Three different approaches were used to evaluate the catabolism of rabbit serum interferon (IFN) by the kidneys. In normal rabbits the disappearance of exogenous IFN from plasma was very rapid; it was significantly slower after bilateral nephrectomy. The IFN level in arterial blood was always higher than in renal venous blood: the mean renal extraction rate of IFN in the rabbit, with a renal plasma flow of 9 ml/min, was .apprx. 1 ml/min. A selective and reversible tubular damage induced by maleate before i.v. administration of IFN significantly inhibited luminal uptake of IFN and markedly increases the interferonuria. The kidneys appear to have a highly significant role in IFN filtration, catabolism and excretion.

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