Contrasting patterns of sequence divergence and base composition betweenDrosophilaintrons and intergenic regions
- 1 August 2006
- journal article
- Published by The Royal Society in Biology Letters
- Vol. 2 (4) , 604-607
- https://doi.org/10.1098/rsbl.2006.0521
Abstract
Two non-coding DNA classes, introns and intergenic regions, of Drosophila melanogaster exhibit contrasting evolutionary patterns. GC content is significantly higher in intergenic regions and affects their degree of nucleotide variability. Divergence is positively correlated with recombination rate in intergenic regions, but not in introns. We argue that these differences are due to different selective constraints rather than mutational or recombinational mechanisms.Keywords
This publication has 23 references indexed in Scilit:
- GC-Biased Segregation of Noncoding Polymorphisms in DrosophilaGenetics, 2006
- Adaptive evolution of non-coding DNA in DrosophilaNature, 2005
- Codon Bias and Noncoding GC Content Correlate Negatively with Recombination Rate on the Drosophila X ChromosomeJournal of Molecular Evolution, 2005
- Inferring the Effects of Demography and Selection on Drosophila melanogaster Populations from a Chromosome-Wide Scan of DNA VariationMolecular Biology and Evolution, 2005
- Insertion/Deletion and Nucleotide Polymorphism Data Reveal Constraints in Drosophila melanogaster Introns and Intergenic RegionsGenetics, 2005
- Patterns of Polymorphism and Divergence from Noncoding Sequences of Drosophila melanogaster and D. simulans: Evidence for Nonequilibrium ProcessesMolecular Biology and Evolution, 2004
- Patterns of Evolutionary Constraints in Intronic and Intergenic DNA of DrosophilaGenome Research, 2004
- DNA Repair in DrosophilaThe Journal of cell biology, 2000
- Adaptive protein evolution at the Adh locus in DrosophilaNature, 1991
- On the number of segregating sites in genetical models without recombinationTheoretical Population Biology, 1975