High-Affinity Choline Transport in Proteoliposomes Derived from Rat Cortical Synaptosomes
- 27 August 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4562) , 843-845
- https://doi.org/10.1126/science.7100928
Abstract
Functional high- and low-affinity choline transport processes from rat cortical plasma membranes were reconstituted in phosphatidylcholine bilayer liposomes. The high-affinity choline transporter demonstrated a pharmacological profile and ion dependency that were identical to those of intact synaptosomes. This preparation may be used to further characterize choline transport and, with appropriate supplementation, to investigate the release of acetylcholine in the absence of synaptic vesicles.This publication has 13 references indexed in Scilit:
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