Advances in epithelial kinetics—An oral view

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Abstract
There is growing evidence that the basal layer of stratified squamous epithelia consists of cells of differing proliferative capacities and behavior. These can be classified as stem cells, transient amplifying cells and post-mitotic maturing cells, the most important of which appear to be the stem cells, which may be present throughout life and are responsible for all cell production under steady-state conditions. Recent stem cell concepts are reviewed for epidermis, intestinal crypt and oral mucosa and are compared with tissues such as bone marrow and testes which have for some time been thought to operate in a similar manner. These concepts are applied to several pathological conditions of [mouse] oral epithelia in an attempt to explain some of the changes observed.