Sickle Cell Haemoglobin D Punjab Disease: S from Ghana and D from England

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Abstract
Two femalc siblings with hemolytic anemia are described, one aged 2 years, the other 11 months. The older child had symptoms of sickle cell crisis with hand foot syndrome. Blood from both siblings showed the presence of hemoglobin S and hemoglobin D as well as 5% fetal hemoglobin in the older child and 20% in the asymptomatic sibling. The mother, a Ghanaian, had sickle cell trait and the father, an Englishman, hemoglobin D trait. The hemoglobin D was identified as hemoglobin D Punjab by fingerprinting. The interaction of hemoglobin S and various hemoglobins D is discussed.