Pharmacologically active sulfoximides: 5-hexyl-7-(S-methylsulfonimidoyl)xanthone-2-carboxylic acid, a potent antiallergic agent

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Abstract
The anti-allergic activity of some xanthone derivatives containing a sulfoximide substituent was investigated. While 2-(S-methylsulfonimidoyl)xanthone itself was inactive, a series of 7-(S-methylsulfonimidoyl)-xanthone-2-carboxylic acids showed good levels of activity in the [rat] passive cutaneous anaphylaxis screen. N-substituted sulfoximide derivatives were less active than the corresponding unsubstituted compounds. The activity of the 7-(S-methylsulfonimidoyl)xanthone-2-carboxylic acids could be enhanced by the introduction of an alkyl or alkoxy substituent at C-5. 5-Hexyl-7-(S-methylsulfonmidoyl)xanthone-2-carboxylic acid may be an anti-asthmatic agent.