HYPOPROTHROMBINEMIA INDUCED IN SUCKLING RATS BY FEEDING 3,3'-METHYLENEBIS(4-HYDROXYCOUMARIN) AND ACETYLSALICYLIC ACID TO THEIR MOTHERS

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Abstract
Hypoprothrombinemia and hemorrhage was induced in suckling rat pups and rata given the anticoagulant, 3,3[image]-methylenebis(4-hydroxycoumarin). By administering vit. K to the mother the extent of the hypoprothrombinemia induced in the pups was markedly reduced. Hypoprothrombinemia can also be induced in suckling rat pups by giving large quantities of acetylsalicylic acid to the mother. The possible bearing of these findings on the clinical use of 3,3[image]-methylenebis(4-hydroxycoumarin) is indicated.

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