Erythrocyte Glutathione Peroxidase in Subjects of Mediterranean Origin

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Abstract
Erythrocyte glutathione peroxidase (GSH-Px) was assayed in subjects of Mediterranean origin and the distribution of the data obtained seems to confirm the existence of 2 alleles coding for low and high enzyme activity. In order to define the limits of expected genotypes less arbitrarily families were studied where parents'' genotypes could define that of the children. Gene frequencies were calculated from genotype frequencies of an unrelated population and from crossings distribution by the Hardy-Weinberg equation. A good agreement was observed between gene frequencies obtained by these 2 different methods.