Stereoselective Synthesis of the Brassinolide Side Chain by the Use of a 5-Exo-α-Silyl Radical Cyclization - Protiodesilylation Sequence
- 1 August 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (08) , 850-852
- https://doi.org/10.1055/s-1995-5095
Abstract
The stereoselective synthesis of the steroid having the brassinolide side chain 2 has been achieved from readily available aldehyde 7 in 8 steps and 31% overall yield, featuring a 5-exo-mode of α-silyl radical cyclization - protiodesilylation sequence as a means for the key stereoselective installment of the 24-methyl group.Keywords
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