Proximal Tubular Hypertrophy in a Case of Acute Leukemia of Childhood: A Study by Microdissection

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Abstract
The proximal tubules of the kidneys from a child who died of acute leukemia were found to be significantly hypertrophied. This finding coincides with evidence presented by Sternby and by Frei and associates, that the renal enlargement frequently encountered in leukemia is not necessarily the sole result of leukemic infiltration, edema, or hemorrhage. The structural glomerulotubular balance of the nephrons in these kidneys approached that of an adult. The child, under rather standardized therapy, including prednisone, had survived for 17 months following diagnosis. The cause of intrinsic renal hypertrophy in leukemia is not clear.

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