THERAPY IN HEMORRHAGIC SHOCK: EFFECTS OF SUPPLEMENTATION OF WHOLE BLOOD TRANSFUSION WITH GLUCOSE AND WITH SODIUM BICARBONATE

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Abstract
Three groups of dogs were subjected to hemorrhagic shock of comparable degree of severity as measured by stress indices. One series (12 dogs) was treated with whole blood transfusion, the 2d (10 dogs) with whole blood transfusion plus NaHCO3 (0.5 g./kg. body wt.) and the 3d (11 dogs) with whole blood transfusion plus glucose (0.54 g./kg. body wt.). The influence of such treatment on the rate of recovery was based on physiol. changes occurring in the ensuing 4-hr. period. Periodic detns. of plasma bicarbonate content, protein and inorganic PO4, as well as whole blood lactate, pyruvate, pH, and glucose were carried out. Similar periodic observations were made on blood pressure, heart rate, respiratory rate, and the volume of urine formed. The mortality and rates of recovery in the 3 groups of animals were comparable The results indicate that the 2 supplemental agents, when used under the conditions of these expts.,cannot be considered to be of great effectiveness as therapeutic adjuncts to whole blood transfusion in the treatment of hemorrhagic shock.

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