Inhibition of Azo Dye Carcinogenesis by Adrenalectomy and Treatment With Desoxycorticosterone Trimethylacetate.

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Abstract
The purpose of this study was to determine the effects of adrenalectomy and desoxycorticosterone on the course of liver carcinogenesis in Long-Evans rats fed 3''-methyl-4-dimethyl-aminoazobenzene. Large doses of long-acting desoxycorticosterone trimethylacetate (DCT) given subcutaneously and intermittently, over a 4 month period, had little or no effect on liver size in azo-dye-fed rats; all livers were enlarged and cancerous. Similar treatment of totally adrenalectomized rats gave protection against the carcinogenic influence of the azo dye; livers were essentially normal in size and appearance. However, the presence of adrenal accessories allowed the carcinogenic process to proceed in treated rats fed azo dye. Total adrenalectomy appeared to be the key factor in inhibiting azo dye carcinogenesis.