Reactions at Only One of Two Equivalent Functional Groups

1 January 1980

journal article
research article
Published by Taylor & Francis in Synthetic Communications

Vol. 10 (10) , 767-771
https://doi.org/10.1080/00397918008061841

Abstract

A common problem encountered by synthetic chemists is to carry out a reaction at just one of two similar functional groups in the substrate molecule. Examples include protection/deprotection of just one hydroxyl group in a diol, addition to only one carbonyl of a diketone, etc. The problem, as depicted below, is to find conditions which maximize formation of the monoproduct (XP) while minimizing the amounts of diproduct (P₂) and starting material (X₂).

Keywords

REACTIONS
EQUIVALENT FUNCTIONAL GROUPS
TWO EQUIVALENT FUNCTIONAL

This publication has 1 reference indexed in Scilit:

Kinetics and Mechanism, Second Edition
The Journal of Physical Chemistry, 1961