Assignment of resonances for ‘acute‐phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma
Open Access
- 11 May 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 215 (2) , 311-315
- https://doi.org/10.1016/0014-5793(87)80168-0
Abstract
Broad resonances at 2.04 and 2.08 ppm in 500 MHz Hahn spin‐echo 1H NMR spectra of human blood plasma are assigned to the N‐acetyl groups of mobile carbohydrate side‐chains (largely N‐acetylglucosamine and N‐acetylneuraminic acid) of glycoproteins such as α1,‐acid glycoprotein. Their intensities in spin‐echo spectra correlate with clinical conditions in which an elevation of the level of ‘acute‐phase’ glycoproteins is expected, and so may be of value in the study of certain diseases.Keywords
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