Nitric oxide induces light-adaptive morphological changes in retinal neurones

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Abstract
THIS study tested the possible involvement of nitric oxide (NO) in light-adaptive morphological changes in the outer retina of a cyprinid fish, the roach. Isolated retinae were treated in the dark by either of two NO-donor compounds (S-nitroso-n-acetylpenicillamine, and sodium nitroprusside), and then studied by light, and electron microscopy; similar results were obtained in both cases. Application of NO induced contraction of cone photo-receptor myoids (i.e. retinomotor movements), and formation of horizontal cell spinules. Accordingly the cone index, and the spinule/ribbon ratio showed 15–20%, and 49–95% change, respectively, compared with controls. These results are consistent with involvement of NO in the light adaptation process in the outer retina of teleost fish.

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