THE MECHANISM OF THE COAGULANT ACTION OF DABOIA VENOM

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Abstract
The coagulant action of Daboia venom on citrated and recalcified bovine and other mammalian plasmas was studied. The high coagulant potency of the venom was dependent on the presence of Ca ions, but was independent of the presence of formed platelets. The venom did not function as a prothrombin substitute. The coagulant action of the venom was syner-gistic with that of tissue extracts, of platelets, of purified cephalin, and of various commercial coagulants. The venom exhibited no synergistic reaction with lecithin. In the presence of the venom the activity of certain thromboplastic substances, impaired by heating, extraction with ether, or prolonged aging, was partially or wholly restored. The coagulant mechanism of the venom was distinct from that of thrombin, of prothrombin, or of thromboplastic substances, and from that of trypsin, of papain, or of the snake venoms which resembled these enzymes in their coagulant action. The coagulant action of the venom may involve a chemical or physical interaction with cephalin through which the action of cephalin on prothrombin is in turn facilitated.

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