Long‐term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR and clinical response.

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Abstract
1 After 12 months cyclophosphamide administration the serum sulphydryl concentrations increased in all of twelve rheumatoid patients treated, and returned towards the normal range in eleven. 2 A decrease was observed in the technetium index, the erythrocyte sedimentation rate, and joint count. 3 Long‐term cyclophosphamide‐induced serum SH increase may represent a specific change in the process of the rheumatoid disease activity, possibly involving the pathogenic B cells.