Real and artificial immune systems: computing the state of the body
- 1 July 2007
- journal article
- opinion
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 7 (7) , 569-574
- https://doi.org/10.1038/nri2102
Abstract
Here I present the idea that the immune system uses a computational strategy to carry out its many functions in protecting and maintaining the body. Along the way, I define the concepts of computation, Turing machines and system states. I attempt to show that reframing our view of the immune system in computational terms is worth our while.Keywords
This publication has 60 references indexed in Scilit:
- Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informaticsJournal of Clinical Investigation, 2007
- Emergent Dynamics of Thymocyte Development and Lineage DeterminationPLoS Computational Biology, 2007
- Thymic rejuvenation and the induction of tolerance by adult thymic graftsProceedings of the National Academy of Sciences, 2006
- Explaining a complex living system: dynamics, multi-scaling and emergenceJournal of The Royal Society Interface, 2006
- Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injuryProceedings of the National Academy of Sciences, 2006
- Clearance of apoptotic and necrotic cells and its immunological consequencesApoptosis, 2006
- Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling MethodPLoS Computational Biology, 2006
- Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signalingJournal of Clinical Investigation, 2006
- An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune SystemCell, 2005
- Modelling viral and immune system dynamicsNature Reviews Immunology, 2002