INHIBITION OF SYNAPTIC TRANSMISSION BY MORPHINE AND ITS ANTAGONISM BY CA++ IN THE ISOLATED SYMPATHETIC-GANGLION OF FROG AND RAT

  • 1 January 1980
    • journal article
    • research article
    • Vol. 55  (4) , 379-384
Abstract
Synaptic transmission is inhibited by morphine in isolated sympathetic ganglia of frog and rat. This action of morphine can competitively be antagonized by naloxone, nalorphine and by increasing the Ca2+ concentration of the medium. The morphine antagonistic action of Ca2+ can be suspended by Mg2+, applied in an equimolar concentration. Morphine inhibits synaptic transmission by shifting the ionic balance necessary for transmitter release.

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