Zinc, Copper, Manganese, and Selenium Metabolism in Patients with Human Growth Hormone Deficiency or Acromegaly

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Abstract
This study was designed to evaluate trace metal metabolism in patients with known abnormalities of human growth hormone (hGH). The mean concentration of Zn in plasma and urine decreased in patients with hGH deficiency after hGH injection; after adenomectomy, in patients with acromegaly, Zn increased in plasma, remained the same in erythrocytes and decreased in urine. There was a negative correlation between plasma Zn and serum hGH levels and a positive correlation between urinary Zn excretion and serum hGH levels in acromegaly. In hGH deficiency, the Cu content remained unchanged in plasma and erythrocytes and rose in urine after treatment; in acromegaly, the Cu content increased in plasma and remained unchanged in erythrocytes and urine after surgery. The mean concentration of erythrocyte Mn did not change significantly after treatment in patients with hGH deficiency or acromegaly, but the pre-hGH treatment level of erythrocyte manganese in hGH deficiency was lower than in the controls. Plasma Se concentrations were decreased in hGH deficiency and increased in acromegaly patients after therapy. hGH affects the metabolism of Zn, Cu, Mn and Se.

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