Differentiation of cartilage and bone from common germinal cells. I. The role of acid mucopolysaccharide and collagen

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Abstract
The differentiation of cartilage and bone from common germinal cells on the membrane bones of the embryonic chick has been investigated to test the hypothesis that acid mucopolysaccharides (chondroitin sulphate) and collagen play a role in controlling the pathways of differentiation open to the germinal cells. Injection of cortisone acetate was used to suppress sulphation of chondroitin to chondroitin sulphate and injection of vitamin C to stimulate collagen synthesis. Of the membrane bones studied 60–80% exhibited suppression of chondrogenesis, indicating that chondroitin sulphate and/or collagen play important roles in the control of chondrogenesis.Mechanical stimulation and hypoxia have been related to chondroitin sulphate synthesis in proposing a mechanism to explain the differentiation of cartilage and bone from common germinal cells.