CONNECTIVE-TISSUE ACTIVATION .8. EFFECTS OF TEMPERATURE STUDIED INVITRO

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (1) , 5-9
Abstract
The effects of increasing environmental temperature were studied in 2 normal and 2 rheumatoid human synovial cell cultures. Control cultures showed an increased rate of hyaluronate synthesis and glycolysis as temperature was increased from 30.degree. C-39.degree. C. Cultures which were activated (stimulated by a connective tissue activating peptide) showed an especially striking increase in hyaluronic acid synthesis, glucose uptake and lactate formation at 36.degree. C-38.degree. C. Small changes in joint temperature may be associated with profound alterations in synovial metabolic activity.