Asymmetric Cyclopropanation ofE-Olefins Using a Copper Complex of an Optically Active Bipyridine as a Catalyst
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (09) , 638-640
- https://doi.org/10.1055/s-1993-22553
Abstract
Cyclopropanation of E-olefins with diazoacetate in the presence of the copper complex of C2-symmetric bipyridine (3) was found to give the corresponding cis-cyclopropanecarboxylates of good to high optical purities as major products, differing from the reaction with copper complex of structurally similar bis(oxazolines). For example, the Cyclopropanation of trans-ß-methylstyrene and trans-anethole with t-butyl diazoacetate gave the corresponding cis-isomers of >99% ee as major products, respectively.Keywords
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