Asymmetric Nucleophilic Acylation with Metalated Chiral Amino Nitriles: Enantioselective Synthesis of 1,4-Diketones via Asymmetric Michael Addition
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (10) , 837-839
- https://doi.org/10.1055/s-1992-21511
Abstract
Conjugate addition of lithiated chiral α-amino nitriles 4 to cyclohexenone 2 afforded 1,4-diketones 6 in good overall yields and with high enantiomeric excesses. The absolute configuration was confirmed by X-ray structure analysis of the Michael-adduct 5b.Keywords
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