Estrogenic Inhibition of the Hepatic Synthesis ofα2uGlobulin in the Rat
- 1 December 1975
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 97 (6) , 1501-1508
- https://doi.org/10.1210/endo-97-6-1501
Abstract
The hepatic synthesis of the androgen-dependent urinary protein in the rat, called .alpha.2u globulin, is strongly inhibited by estrogens. In mature male rats, treatment with estradiol-17.beta. (0.5 .mu.g/g body weight) completely inhibits .alpha.2u synthesis within 6-7 days. Following withdrawal of estrogen treatment .alpha.2u synthesis is not reinitiated for approximately 20 days. Parabiotic joining of estrogen-suppressed male rats with their normal littermates within this lag period fails to change the preparabiotic pattern of .alpha.2u synthesis in the respective partners. Besides estradiol-17.beta., other estrane derivatives such as estrone, estriol and estradiol-17.alpha. also inhibited the synthesis of .alpha.2u globulin. All of the above estrane derivatives which inhibit .alpha.2u synthesis also inhibited the uptake of 5.alpha.-dihydrotestosterone by the hepatic cytosol androgen binding protein of the mature male rat. Unlike cycloheximide, a known translational inhibitor, estradiol-17.beta. does not inhibit .alpha.2u synthesis in the perfused rat liver.This publication has 1 reference indexed in Scilit:
- Identification of Rat Urinary Proteins by Zone and Immunoelectrophoresis.Experimental Biology and Medicine, 1966