Inhibition of Varicella-Zoster Virus (VZV) Glycoprotein Expression by a Human Monoclonal Antibody against VZV Glycoprotein III
- 1 November 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 168 (5) , 1256-1259
- https://doi.org/10.1093/infdis/168.5.1256
Abstract
Effects of human monoclonal antibodies (MAbs) against varicella-zoster virus (VZV) glycoproteins (gp) on VZV glycoprotein expression were analyzed by flow cytometry. Human embryonic fibroblast (HEF) cells were inoculated with cell-free VZV and cultured in the presence of human MAbs. While human MAbs directed against gpl (V2) and -II (VI) did not affect VZV expression, a human MAb against gpIII (V3) inhibited expression ofVZV gpI, -II, -III, and -IV. V3 also inhibited spread of VZV from infected to uninfected cells. Interferon-α, -β, and -γ and tumor necrosis factor-α were able to synergize with V3 and inhibit VZV gp expression. These results suggest that human MAb V3 may beuseful for passive prophylaxis against VZV infection and for treatment of severe VZV infection.Keywords
This publication has 0 references indexed in Scilit: