Efficacy of a new long-acting formulation of ivermectin and other injectable avermectins against induced Psoroptes ovis infestations in cattle
- 1 December 2002
- journal article
- clinical trial
- Published by Springer Nature in Zeitschrift Fur Parasitenkunde-Parasitology Research
- Vol. 88 (12) , 1061-1065
- https://doi.org/10.1007/s00436-002-0713-5
Abstract
Two studies describe the therapeutic and protective efficacy of commercially available, injectable avermectins against Psoroptes ovis infestations. In each study, six untreated calves were compared to groups of six calves each treated with ivermectin long-acting injectable (LAI) 3.15% w/v solution, generic long-acting (LA) ivermectin 1% w/v solution or 1% w/v doramectin solution. Treatments were carried out according to the manufacturer's instructions at 1 ml/50 kg body weight. Live mites in skin scrapings were counted prior to treatment and at weekly intervals for 8 weeks thereafter in the therapeutic study, or at 15, 21 and 28 days after P. ovis challenge which occurred 28 days post-treatment in the study to compare protective efficacy. P. ovis infested calves treated with ivermectin LAI had significantly (PP. ovis at 8 weeks after treatment. No P. ovis mites were recorded on the calves treated prophylactically with ivermectin LAI. In contrast, five or all of the six calves treated prophylactically with generic LA ivermectin or doramectin, respectively, were positive for P. ovis mites at the end of the study. Calves treated prophylactically with ivermectin LAI gained significantly more weight than the untreated controls.Keywords
This publication has 0 references indexed in Scilit: