ALPHA-TOCOPHEROL PRETREATMENT INCREASES ADRIAMYCIN BONE-MARROW TOXICITY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 29  (6) , 189-191
Abstract
.alpha.-Tocopherol increases survival duration and decreases cardiotoxicity and cell membrane lipid peroxidation in adriamycin treated leukemic mice. The interacting effects of free .alpha.-tocopherol-adriamycin or .alpha.-tocopherol acetate-adriamycin on the latter''s inhibition of mouse bone marrow (NCFU) and P388 leukemic (LCFU) stem cell growth was studied. Free .alpha.-tocopherol or .alpha.-tocopherol acetate, 85 IU, was given i.p. to normal or leukemic DBA/2 mice 24 h prior to i.v. adriamycin, 2-12 mg/kg. NCFU and LCFU assays were carried out as previously described. Free .alpha.-tocopherol and .alpha.-tocopherol acetate caused a significant (P < .02) increase in adriamycin toxicity to NCFU, whereas .alpha.-tocopherol acetate did not significantly increase adriamycin''s inhibition of LCFU. Free .alpha.-tocopherol or .alpha.-tocopherol acetate may cause a potentiation of adriamycin''s bone marrow toxicity.