PBDX is the XG blood group gene
- 1 November 1994
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 8 (3) , 285-290
- https://doi.org/10.1038/ng1194-285
Abstract
We have identified the Xga antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as PBDX. In indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a-) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xga. Therefore, by its identity with PBDX, Xga is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of MIC2 which is tightly linked to XG. PBDX is renamed here XG.Keywords
This publication has 35 references indexed in Scilit:
- The biochemical characterization of E2, a T cell surface molecule involved in rosettesEuropean Journal of Immunology, 1989
- The pseudoautosomal boundary in man is defined by an Alu repeat sequence inserted on the Y chromosomeNature, 1989
- Multipoint linkage analysis of steroid sulfatase (X-linked ichthyosis) and distal Xp markersGenomics, 1987
- Recombination between the X and Y chromosomes: implications for the relationship between MIC2, XG and YGAnnals of Human Genetics, 1987
- The Xga antigen on red cells and fibroblastsCytogenetic and Genome Research, 1978
- Expression of the Xga antigen on Cells in culture and its segregation in somatic cell hybridsAnnals of Human Genetics, 1974
- An inhertited X-autosome translocation in manAnnals of Human Genetics, 1971
- Xg Locus : Failure to detect Inactivation in Females with Chronic Myelocytic LeukaemiaNature, 1970
- A SEX-LINKED BLOOD GROUPThe Lancet, 1962