Stimulatory Effect of Prostaglandin E2 on LH Release in the Rat: Evidence for Hypothalamic Site of Action

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Abstract
The intravenous administration of prostaglandin E2 (PGE2; 100 µg/rat) to immature male and female rats increased the serum level of luteinizing hormone (LH). This effect was prevented by the prior administration of an antiserum to the hypothalamic gonadotropin-releasing hormone. LH release from rat pituitaries in vitro was not stimulated by PGE2 (10 µg/ml). It is inferred that the stimulatory effect of PGE2, on LH release is not a direct one on the pituitary gland, but is exerted at the level of the hypothalamus.

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