No evidence of direct cardiac action of leucine-enkephalin in canine heart-lung preparation.

1 January 1984

journal article
Published by Physiological Society of Japan in The Japanese Journal of Physiology

Vol. 34 (2) , 351-355
https://doi.org/10.2170/jjphysiol.34.351

Abstract

Intravenous administration of leucine-enkephalin (30 micrograms/kg) caused significant decreases in mean blood pressure, cardiac output, and left ventricular dP/dt in intact dogs. However, cardiovascular effects of leucine-enkephalin (30-120 micrograms/kg) did not occur in the heart-lung preparation uninfluenced by extracardiopulmonary factors. These results provide no evidence of a direct cardiac action of leucine-enkephalin.

Keywords

LEUCINE ENKEPHALIN
CARDIAC OUTPUT
BLOOD PRESSURE
DIRECT CARDIAC ACTION
ACTION OF LEUCINE
DOGS
LUNG

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