Metformin
- 29 February 1996
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 334 (9) , 574-579
- https://doi.org/10.1056/nejm199602293340906
Abstract
Metformin (dimethylbiguanide) is an orally administered drug used to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus (NIDDM).1 It improves insulin sensitivity and thus decreases the insulin resistance that is prevalent in NIDDM. The efficacy of glycemic control achieved with metformin is similar to that achieved with sulfonylureas, although their modes of action differ. Metformin can be used either as initial therapy or as an additional drug when sulfonylurea therapy alone is inadequate. In this article we shall discuss the pharmacology and clinical use of metformin, which is now available in the United States.The Burden of Non-Insulin-Dependent . . .This publication has 60 references indexed in Scilit:
- Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year studyDiabetes Research and Clinical Practice, 1995
- Therapeutic Comparison of Metformin and Sulfonylurea, Alone and in Various Combinations: A double-blind controlled studyDiabetes Care, 1994
- Standards of Medical Care for Patients With Diabetes Mellitus: American Diabetes AssociationDiabetes Care, 1994
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- Long-Term Complications of Diabetes MellitusNew England Journal of Medicine, 1993
- Biguanides and NIDDMDiabetes Care, 1992
- Prevalence of micro- and macroalbuminuria, arterial hypertension, retinopathy and large vessel disease in European Type 2 (non-insulin-dependent) diabetic patientsDiabetologia, 1991
- Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yrDiabetes, 1987
- Mortality and survival in Type 2 (non-insulin-dependent) diabetes mellitusDiabetologia, 1987
- Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up StudyDiabetes, 1974