Antigens in Penicillin Allergy

Publisher Website
Google Scholar
Abstract
The effects of the different acyl side chains of azidocillin, ampicillin and benzylpenicillin on the immunogenic potency of penicilloylated [PO] antigens and on the specificity of the developed antibodies were investigated in CBA mice. The antigens used were penicilloylated bovine .gamma.-globulin (BGG), bovine serum albumin (BSA) and human serum albumin (HSA). Immunization was performed with injection of high doses of antigens together with adjuvant or by injection of minute amounts of antigen over periods of 10 days. Ig[immunoglobulin]E antibodies were recorded with PCA [passive cutaneous anaphylaxis] in rats and IgG antibodies were measured with a double antibody assay. The nature of the carrier and the number of epitopes influenced the development of antibodies irrespective of the immunization schedule used. The immunogenic activity of the PO-BSA antigens was related to the epitope density. The PO-BSA antigens were, in contrast to the PI-BGG antigens, weak immunogens in the CBA mice. The acyl side chains of the different penicillins influenced the induction and specificity of the IgE antibody responses obtained after daily treatment.

This publication has 3 references indexed in Scilit: