Hyperplastic Nodules and Adenomas of Exocrine Pancreas in Azaserine-Treated Rats2
- 1 August 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 53 (2) , 573-577
- https://doi.org/10.1093/jnci/53.2.573
Abstract
Long-term studies of the carcinogenicity of azaserine in rats were undertaken to develop a model of adenocarcinoma of the pancreas. Rats were treated for 6 weeks to 6 months with once or twice weekly intraperitoneal azaserine injections. Single doses were 5–25 mg/kg; total doses were 120–300 mg/kg. All of 18 rats autopsied 3½, 6, or 8 months after initiation of treatment had nodular groups of atypical exocrine cells which seemed to represent hyperplastic foci, and 3 rats had small exocrine adenomas. No malignant tumors were found. One of 6 control rats contained 1 hyperplastic nodule in exocrine pancreas.Keywords
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