Unipolar Electrogram Models for Prediction of Outcome in Radiofrequency Ablation of Accessory Pathways

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Abstract
Meticulous catheter positioning dose to the accessory pathway is essential for successful radiofrequency ablation. The aim of this study was to identify local unipolar electrogram characteristics predictive of radiofrequency ablation outcome, enabling more accurate accessory pathway localization and catheter positioning. So far mainly bipolar electrogram parameters have been evaluated, stressing the importance of the presence of an accessory pathway potential. However, especially in the absence of this parameter, the unipolar recording mode can be expected to hold severol advantages. Nine local unipolar electrogram characteristics were analyzed in preexcited sinus rhythm directly preceding radiofrequency pulses in 35 consecutive patients with a manifest occessory atrioventricular pathway. A total of 1,230 unipolar electrogram complexes were analyzed and recorded at 138 ablation sites. Ablation was successful in 30/35 patients (86%). Multivariate analysis provided two unipolar models for prediction of ablation outcome: in Model I, sites with a suspected accessory pathway potential, local AV interval ≤ 30 msec and catheter stability had 76% probability of success, but no more than 1% in their absence. In contrast, using the bipolar recording mode, presence of a suspected accessory pathway potential was the only one of these parameters shown to differentiate between successful and unsuccessful sites, with a predicted chance of success of 48%. Model II, not requiring assessment of possible accessory pathway potentials, showed a 63% probability of success for the combination of initial positivity of the local ventricular signal ≤ 0.1 mV, AV interval ≤ 30 msec, and catheter stability, but no more than 7% in their absence. Moreover, gradual decrease of initial ventricular positivity and AV interval while approaching a subsequently successful site allows the use of these parameters as dynamic mapping tools. Local unipolar electrogram parameters may thus facilitate precise accessory pathway localization and catheter positioning while offering important information supplementary to the bipolar mode, and enable accurate prediction of ablation outcome at a given site also in the absence of accessory pathway potential recording.