Enzyme-Catalyzed Enantioselective Diaryl Ketone Reductions
- 16 December 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (2) , 335-338
- https://doi.org/10.1021/ol0627909
Abstract
The synthesis of diarylmethanols via the reduction of a range of substituted benzophenone and benzoylpyridine derivatives with ketoreductase enzymes (KREDs) has afforded chiral products with high yield (>90%) and ee (up to >99%). Ortho, meta, and para substitutions with a variety of electron-donating, electron-withdrawing, and halogen groups were examined. Substitution at the ortho position and/or highly electronically dissymmetric molecules were not required for good selectivity, as is the case with conventional chemical catalyst reductions.Keywords
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