Antileukemic effect of alkyl phospholipids
- 1 October 1983
- journal article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 11 (2) , 77-79
- https://doi.org/10.1007/bf00254249
Abstract
Alkyl ethyleneglycophospholipids induced differentiation in vitro of mouse myeloid leukemia M1 cells into mature granulocytes and macrophages. The compounds also prolonged the survival of syngeneic SL mice inoculated with M1 cells. Although in mice with florid leukemia these compounds alone scarcely affected survival, administration of dodecyl ethyleneglycophospholipid with pyridinioethyl as a polar group plus actinomycin D significantly prolonged survival.Keywords
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