Duration of Secretion of Bacteriostatic Drugs in Milk. I. Penicillin, Following Oral and Parenteral Administration

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Abstract
Intra-muscular injection of milking cows at the rate of 3000 unit/lb body weight of procaine penicillin G in sesame oil with 2% aluminum mono-stearate (penicillin in oil) and potassium penicillin G in aqueous sus-pension (aqueous penicillin) resulted in penicillin detectable by cylinder assay with Sarcina lutea in the milk for maximum intervals of 96 and 72 hr, respectively. Intravenous injection of 2000 units of aqueous penicillin/lb body wt. resulted in detectable penicillin in the milk for a maximum of 44 hr. Penicillin was detectable in milk a maximum of 27 to 31 hr following intrauterine infusion of 1,000,000 units of aqueous penicillin and of 86 hr following feeding of a single dose of 10,000,000 units of penicillin in oil mixed with the concentrate feed. Correlations between the duration of secretion of milk containing penicillin and milk production, fat content of the milk, and body weight were non-significant (P > .05) for all methods of administration.

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