Influence of the liver on regulation of glomerular pressure in the toad

Publisher Website
Google Scholar
Abstract
The effect of plasma volume (PV) expansion on toad''s glomerular pressure index (GPI) was studied. PV expansion in normal animals is followed by a rise in GPI. When an isolated kidney is perfused by blood of a donor toad, whose renal arteries and veins are ligated, expansion of the donor''s PV induces an increase in the isolated kidney''s GPI. This suggests an increase in the blood of a glomerular pressure substance (GPS) of extrarenal origin. The orderly exclusion of various capillary territories was without effect. The glomerular pressor response could only be abolished by the excision of the liver, suggesting that GPS probably originates in the liver.

This publication has 1 reference indexed in Scilit: