Fate of P32-Labeled Bayer 21/199 in the White Rat1

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Abstract
The fate of Bayer 21/199, O-(3-chloro-4-methylumbelliferone) O, O-diethyl phosphorothioate, has been studied by administering the p32-labeled compound orally to white rats at an average dosage of 20 mg. per kg. of body weight. The compound was rapidly metabolized and excreted. About 78% of the radioactivity of the original dose was excreted via the urine within 24 hours. Paper chromatographic analyses indicated that none of the radioactivity in the urine was Bayer 21/199 but was associated with more polar compounds. Lesser amounts of radioactivity were found in the feces, bile, lymph, and blood. Among samples of various tissues taken 24 hours after dosage, small but significant amounts of radioactivity were found in bone, liver, and kidney.

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