Plasma bupivacaine concentrations during caudal analgesia and ilioinguinal‐iliohypogastric nerve block in children
Open Access
- 1 August 1988
- journal article
- Published by Wiley in Anaesthesia
- Vol. 43 (8) , 650-653
- https://doi.org/10.1111/j.1365-2044.1988.tb04150.x
Abstract
Plasma bupivacaine concentrations were measured in 27 children aged 3 ‐7 years who received one of two analgesic regimens for herniotomy or orchidopexy. Analgesia was provided either by caudal epidural bupivacaine 0.2% 2 mg/kg (n = 14) or by ilioinguinal‐iliohypogastric nerve block with bupivacaine 0.5% 1.25 mg/kg (n = 13). Mean (SD) peak venous bupivacaine concentrations were 0.57 (0.17) μg/ml and 0.79 (0.38) μg/ml respectively. Time to peak plasma concentrations were 29.6 (7.9) and 22.3 (10.9) minutes respectively. These concentrations are well below the potentially toxic level of 4.0 μg/ml, but suggest that uptake of bupivacaine is more rapid after ilioinguinal iliohypogastric nerve block than during caudal analgesia.Keywords
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