A New Strategy for Improved Nicotine Vaccines Using Conformationally Constrained Haptens
- 21 May 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (24) , 7164-7165
- https://doi.org/10.1021/ja034805t
Abstract
Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.Keywords
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