Induction of hepatic drug metabolizing enzymes in mammals by pesticides: A review
- 1 January 1980
- journal article
- review article
- Published by Taylor & Francis in Journal of Environmental Science and Health, Part B
- Vol. 15 (6) , 723-754
- https://doi.org/10.1080/03601238009372216
Abstract
The induction of drug metabolizing enzymes in mammals is summarized including both enzymes of the cytochrome P‐450‐dependent microsomal mixed function oxidase system and glutathione S‐transferases. Particular emphasis is placed on the role of pesticides as inducers, the early work being summarized while investigations carried out at North Carolina State University are considered in greater detail. Finally, the possible significance of induction is considered.Keywords
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