PROSTACYCLIN FORMATION BY THE PREGNANT HUMAN MYOMETRIUM
- 1 March 1980
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 87 (3) , 215-218
- https://doi.org/10.1111/j.1471-0528.1980.tb04521.x
Abstract
Human myometrium taken between 15 and 42 weeks of pregnancy released a material in vitro which possessed anti-aggregatory activity. This material parallelled authentic prostacyclin in this action; it possessed a similar stability at alkaline pH and generation of activity was inhibited by indomethacin. Production of the prostacyclin-like material by the myometrium was similar at weeks 15 and 38 of pregnancy but a 4-fold increase in synthesis had occurred by 40 weeks. It is suggested this increase may be important for parturition.Keywords
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